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Skin Cancer Updates

Melanoma: β-blockers cut recurrence risk, boost survival


  • Long-term results confirm earlier findings that the use of β-blockers can significantly reduce the risk for recurrence and mortality in patients with melanoma.

Why this matters

  • β-blockers have promise as a new therapeutic option for patients with melanoma, but randomized trials are needed to confirm these results.

Study design

  • Updated results of a prospective study comprised of 121 patients with stage II–IIIA (T2,N0 or N1,M0) melanoma, with 30 (25%) patients reporting use of β-blockers.
  • Funding: None listed.

Key results

  • Initial results reported that at a median follow-up of 2.5 y, 34% of untreated patients had progressive disease vs only 3% of those using β-blockers.
  • At 8-y follow-up, as reported in the current article, with a median duration of β-blocker use of 7.6 y, 45% of untreated patients had disease progression vs 30% using β-blockers.
  • 32 (35%) untreated patients died from melanoma vs 5 (17%) treated patients.
  • β-blocker use was inversely associated with DFS (HR, 0.37; P=.02) and OS (HR, 0.34; P=.01), in an analysis that was adjusted for confounders including age, sex, Breslow thickness, ulceration, mitoses, and hypertension.



De Giorgi V, Grazzini M, Benemei S, Marchionni N, Geppetti P, Gandini S. β-Blocker use and reduced disease progression in patients with thick melanoma: 8 years of follow-up. Melanoma Res. 2017 Mar 24 [Epub ahead of print]. doi: 10.1097/CMR.0000000000000317. PMID: 28346289

Ailesbury Dublin

David Lloyd Riverview,

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Beech Hill Road,
Donnybrook  Dublin 4.

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Tel:   (01)269 2255 / 2133                                             

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Ailesbury Cork

Holbar House
East Village
Douglas, Cork. 

Eircode T12 HK2C (Google Map)

Tel:   (01)269 2255 / 2133

Galway (021) 4835006

Fax: (01) 218 0857 

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Ailesbury Clinic is now opening monthly at Bellisimo Galway with Dr. Olga O' Driscoll MICGP. Dip. Aesthetic Medicine (right)  




Ailesbury Galway                   

Bellissimo Galway  

Galway Retail Park,

Headford Road, Galway

Eircode TH91 DN3P (Google Map)

Tel:   (01)269 2255 / 2133

Galway (091)568 555

Fax: (01) 218 0857


Specialists in Dermatology and Aesthetic Medicine. We perform minor surgery + skin cancer screen. VHI, Aviva, Laya and Irish Health accepted. Hstopathology is covered by private insurance and performed by dedicated skin histopathologists at St. Vincent's University Hospital, Dublin. Consultation €100  READ MORE 


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